. Author manuscript; available in PMC: 2014 Nov 13.

Published in final edited form as: Transl Res. 2007 Nov 8;151(2):68–78. doi: 10.1016/j.trsl.2007.10.003

Table I.

Studies of experimental gene transfer with ecSOD

Target tissue + condition	Species	Model	Vector	End points	Reference
Aorta + heart failure	rat	in vivo IV	Ad	Restored NO levels and responses to acetylcholine; decreased levels of $O_{2}^{\cdot -}$ and peroxynitrite	16
+ hypercholesterolemia	mouse	in vivo IV	Ad	Did not affect atherogenesis	18
+ aging	rat	in vivo IV	Ad	Decreased vascular $O_{2}^{\cdot -}$	19
+ spontaneous hypertension	rat	in vivo IV	Ad	Decreased levels of $O_{2}^{\cdot -}$ and nitrotyrosine	20
+ LPS treatment	rat	in vivo IV	Ad	Decreased $O_{2}^{\cdot -}$ and LPS-induced adhesion of leukocytes to aortic endothelium	22
+ balloon denudation	rabbit	in vivo local delivery	Ad	Decreased $O_{2}^{\cdot -}$ , neointimal formation, and macrophage infiltration; IV gene transfer did not decrease restenosis	17
Carotid artery + spontaneous hypertension	rat	in vivo IV	Ad	Increased basal NO levels and responses to acetylcholine	20
+ spontaneous hypertension	rat	in vivo IV	Ad	Increased sodium balance and relaxation to acetylcholine; decreased mean arterial pressure	21
+ stroke-prone, spontaneous hypertension	rat	in vivo IV	Ad	Increased NO availability; improved endothelial function	23
Basilar artery + subarachnoid hemorrhage	dog	in vivo cisterna magna	Ad	Failed to prevent delayed cerebral vasospasm	24
Brain	rabbit	in vivo cisterna magna	Ad	Increased SOD activity in cerebrospinal fluid	25
Basilar artery + subarachnoid hemorrhage	rabbit	in vivo cisterna magna	Ad	Decreased cerebral vasospasm	26
Portal vein + acute liver injury	mouse	in vivo IV	ecSOD lipoplexes	Increased serum SOD activity and liver glutathione levels; decreased lipid peroxidation	27
Knee joint + antigen-induced arthritis	rat	ex vivo	ecSOD-expressing synoviocytes	Decreased joint swelling and gelatinase activity; decreased infiltration of inflammatory cells into the synovial membrane	28
+ collagen-induced arthritis	mouse	ex vivo	ecSOD-expressing fibroblasts	Decreased mononuclear cell infiltration and synovial proliferation; improved histologic abnormalities, including destruction of cartilage and bone	29
Heart + myocardial infarction	rabbit	in vivo IV	Ad	Markedly decreased infarct size	30
+ myocardial stunning	rabbit	in vivo IV	Ad	Increased ecSOD levels in the liver; improved left ventricular wall motion	31
Liver + paracetamol-induced damage	mouse	in vivo IV	Ad	Significantly attenuated release of liver enzymes and inhibited necrosis and apoptosis	18
+ ischemia/reperfusion- induced liver injury	mouse	in vivo IV	polylipid nanoparticles	Increased SOD activity and decreased $O_{2}^{\cdot -}$ levels and oxidative stress in liver; decreased enzyme release and improved liver histology	32
Cavernosum + diabetes	rat	in vivo IV	Ad	Decreased $O_{2}^{\cdot -}$ levels	33
Bowel + colitis	mouse	ex vivo	ecSOD-expressing fibroblasts	Increased chance of survival	34

Abbreviations: Ad, adenovirus; IV, intravenous; LPS, lipopolysaccharide.