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. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: J Med Genet. 2013 Oct 7;51(1):10–20. doi: 10.1136/jmedgenet-2013-101951

Table 2.

Above-threshold SCQ scores in male and female RASopathy subjects and healthy siblings

Males/females Males with SCQ≥15 (%) Females with SCQ≥15 (%) OR p Value
All RASopathies 102/109 39 (38) 18 (17) 3.1 0.0003
NF1     26/40   7 (27)   0 (0) – 0.0008
CS     22/21   8 (36)   3 (14) 3.4 0.095
NS     26/22   6 (23)   4 (18) 1.4 0.48
CFC     28/26 18 (64) 11 (42) 2.5 0.0891
Siblings     66/51   0 (0)   0 (0) – 1.0

The percentage of males and females within each group who scored 15 or higher on the SCQ are shown. OR=Odds Ratio showing male compared with female prevalence. One-tailed Fisher’s Exact test p values are calculated as shown.

CFC, cardio-facio-cutaneous syndrome; CS, Costello syndrome; NF1, neurofibromatosis type 1; NS, Noonan syndrome; SCQ, Social Communication Questionnaire.