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. 2014 Sep;11(5):306–323. doi: 10.1177/1479164114542802

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© The Author(s) 2014

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 4. — Changes in eGFR over time in T2DM patients with moderate RI treated with (a) canagliflozin and (b) dapagliflozin. Moderate RI = baseline eGFR ≥30 and <50 mL/min/1.73 m²; Moderate RI = baseline eGFR ≥30 and <60 mL/min/1.73 m². Placebo (circles, solid line), dapagliflozin 5 mg (squares, dashed line) and dapagliflozin 10 mg (triangles, dotted line).

Source: Reprinted by permission from Yale et al.^{86 ©}2013 Blackwell Publishing Ltd; Reprinted by permission from Macmillan Publishers Ltd: Kidney International (Kohan et al.⁸⁷ Copyright^©2014).

CANA: canagliflozin; eGFR: estimated glomerular filtration rate; LS: least squares; PBO: placebo; RI: renal impairment; SE: standard error; T2DM: type 2 diabetes mellitus.