TABLE 4.
Hematological and non-hematological toxicity of concurrent radiation and chemotherapy
| ARM A (N = 52) | ARM B (N = 54) | P* | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| Grade 1, 2 | Grade* 3, 4 | Grade 1, 2 | Grade* 3, 4 | ||||||
|
|
|||||||||
| No. | (%) | No. | (%) | No. | (%) | No. | (%) | ||
| Anemia | 48 | 92.3 | 4 | 7.7 | 53 | 98.1 | 0 | 0 | 0.04 |
| Neutropenia | 17 | 32.7 | 15 | 28.8 | 13 | 24.1 | 14 | 25.9 | 0.74 |
| Febrile neutropenia | / | / | 4 | 7.7 | / | / | 2 | 3.7 | 0.37 |
| Sepsis | / | / | 2 | 3.8 | / | / | 0 | 0 | 0.15 |
| Pneumonia | 0 | 0 | 2 | 3.8 | 0 | 0 | 0 | 0 | 0.15 |
| Thrombocytopenia | 24 | 46.1 | 5 | 9.6 | 27 | 50.0 | 0 | 0 | 0.02 |
| Acute kidney injury | 21 | 40.4 | 1 | 0 | 20 | 37.0 | 0 | 0 | 0.31 |
| Pericarditis | 0 | 0 | 1 | 1.9 | 0 | 0 | 0 | 0 | 0.31 |
| Nausea/vomiting | 6 | 11.5 | 3 | 5.8 | 10 | 18.5 | 4 | 7.4 | 0.73 |
| Esophagitis | 30 | 57.7 | 9 | 17.3 | 39 | 72.2 | 6 | 11.1 | 0.36 |
| Pneumonitis | 1 | 1.9 | 4 | 7.7 | 4 | 7.4 | 1 | 1.8 | 0.16 |
| Neurotoxicity | 6 | 11.5 | 0 | 0 | 13 | 24.1 | 0 | 0 | / |
| Weight loss | |||||||||
| No | 35 | 36 | 0.94 | ||||||
| 1–5% | 7 | 6 | 0.71 | ||||||
| 6–20% | 8 | 8 | 0.93 | ||||||
| 21–31% | 0 | 2 | 0.16 | ||||||
n = number of patients; No. = number;
*
statistical significance for grade 3, 4