FIGURE 8:

A combined plot of end-to-end length averaged over 100 simulations for multiple affinity and nuclear transport receptor configurations in the ABM. Note that, where unspecified, the number of transport receptors was set to the baseline value of nine, distributed uniformly along the length of the mRNA. The x-axis represents the position along the axis perpendicular to the nuclear envelope (z-distance), with x = 0 set at the center of the central channel of the NPC. Left to right, the dashed lines represent the distal edge of the nuclear basket, the nuclear edge of the central channel, the cytoplasmic edge of the central channel, and the distal edge of the cytoplasmic filaments, respectively. Note that low sampling of successful transport events accounts for the increased observed variability in average end-to-end lengths of low Nup-NXF1– affinity transports on the cytoplasmic side.