Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 8;5(4):86. doi: 10.1186/scrt475

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Mienaltowski et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Expression of tendon differentiation markers and matrix assembly genes is generally greater in tendon proper-derived progenitors. RT-qPCR analyses demonstrated greater expression of the tendon markers Scx(A) and Tnmd(B) in tendon proper (TP)-derived progenitors within their respective constructs. However, expression of the vascular marker Emcn(C) was greater in peritenon-derived (PERI) progenitors. Expression of Bgn(D) remains fairly constant across cell sources, while expression for Dcn(E) is greater in TP-derived progenitor-seeded tendon constructs. Expression of FACIT collagens Col12a1(F) and Col14a1(G) is greater early in culture, particularly for TP-derived progenitors. Gene expression for fibril-forming collagens Col1a1(H), Col3a1(I), and Col5a1(J) is greater in TP-derived progenitors. Expression of Col11a1(K) is greatest early in TP-derived progenitors. (Biological replicates, n = 5 to 8; Mann–Whitney-Wilcoxon test – P <0.01, *; P <0.05, #; fold changes and statistical significance further reported in Table 2).