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. 2014 Jul 8;5(4):86. doi: 10.1186/scrt475

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Copyright © 2014 Mienaltowski et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Peritenon-derived progenitor conditioned media stimulates expression of tendon differentiation markers and matrix assembly genes. Treatment of tendon proper-derived progenitors and tenocytes with peritenon-derived progenitor conditioned media (PERI) resulted in increased expression of the tendon markers Scx(A) and Tnmd(B), as well as vascular marker Emcn(C). When tendon proper-derived progenitors and tenocytes were treated with PERI conditioned media, expression of matrix assembly genes increased as a trend for Bgn(D), Dcn(E), Col12a1(F) and Col11a1(K); and significantly for Col14a1(G), Col1a1(H), Col3a1(I) and Col5a1(J). Peritenon-derived progenitors were not stimulated by tendon proper-derived progenitor or tenocyte conditioned media. (Biological replicates, n = 4 to 8; Mann–Whitney-Wilcoxon test relative to control media for each cell type for each gene assayed – P <0.01, *; P <0.05, #).