Table 3.
Mean expression fold differences of PERI constructs given GDF5 versus TP constructs
| Gene | TP 7/PERI 7 + GDF5 | TP 45/PERI 45 + GDF5 |
|---|---|---|
|
Scx
|
64.16
b
|
7.75
b
|
|
Tnmd
|
13.41
b
|
37.85
b
|
|
Emcn
|
0.21
a
|
0.07
b
|
|
Bgn
|
1.67 |
0.59 |
|
Dcn
|
1.69 |
3.26
a
|
|
Col1a1
|
2.81 |
1.96 |
|
Col3a1
|
1.38 |
1.30 |
|
Col5a1
|
1.40 |
1.29 |
|
Col11a1
|
6.46
a
|
6.52
a
|
|
Col12a1
|
2.43 |
2.95 |
| Col14a1 | 0.84 | 0.39 |
Expression Fold Differences represent the ratio of means of (Target Gene/Actb)Group A/(Target Gene/Actb)Group B. PERI: peritenon-derived progenitors; TP: tendon proper-derived progenitors. Days in culture: 7 days in construct (7), 45 days in construct (45); +: with GDF5 supplementation. Statistical significance of fold changes are in bold (aP <0.05; bP <0.01); two-tailed unpaired Mann–Whitney-Wilcoxon tests were performed. Graphical representations of the data are found in Figure 5.