Table 2. Motifs loss rates within and outside modern human recombination hotspots (HapMap).
Motifs | Branch | Na | Rateb | pc | # obs. lossd | # exp. losse | # dBGC lossf | ||
HM | CM | HM | CM | ||||||
Within hotspots | Chimpanzee | 1272 | 724 | 5.5% | 5.4% | 0.994 | |||
Hominini | 1272 | 724 | 3.9% | 4.3% | 0.792 | ||||
Denisovan | 1222 | 693 | 0.8% | 0.4% | 0.485 | ||||
Human | 1222 | 693 | 3.5% | 0.6% | 1.2×10−4 | 43 | 7 | 36 | |
Outside hotspots | Chimpanzee | 3167 | 3669 | 5.2% | 4.9% | 0.605 | |||
Hominini | 3167 | 3669 | 4.9% | 4.0% | 0.109 | ||||
Denisovan | 3013 | 3521 | 1.1% | 0.5% | 0.024 | 32 | 15 | 17 | |
Human | 3013 | 3521 | 1.2% | 0.4% | 3.3×10−4 | 35 | 12 | 23 |
Intact motif count at ancestral node of the branch (cf. Figure 1).
Motif loss rate along the branch.
P-value of proportion test comparing HM vs. CM loss rates along the branch.
Number of observed HM losses.
Number of HM losses expected in absence of dBGC (i.e. based on CM loss rate).
Estimated number of HM losses caused by dBGC (obs. - exp.). NB: these values are reported only for lineages showing evidence of dBGC (p<0.05).