Table 2.
Patients characteristics in individual groups
| G1: Early (N = 52) | G2: Late or no seroconversion (N = 57) | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| P value | P value | ||||
| Age at initial visit (year) | 0-10 (Median 2.8) | 0-44 (Median 28) | < 0.00005 | **** | |
| Gender (Male/Female) | 28/24 | 5/52 | < 0.00005 | 0.001 | |
| ALT level (IU/L) at initial visit | 10-725 (Median 80.5) | 7-767 (Median 23) | < 0.00005 | 0.489 | |
| Duration of follow-up period (year) | 1-21 (Median 10.0)* | 1-25 (Median, 6.0) | 0.6218 | 0.013 | |
| Age at HBe seroconversion | 1-10 (Median 6.5) | 21-34 (Median 25)** | Not done | Not done | |
| Serum HBV DNA level at last visit (log copies/mL) | 2.5-8.7 (Median 4.8)*** | 3.0-9.0 (Median 8.5) | < 0.00005 | 0.003 | |
| Transmission route | Mother-to-child | 43 | 37 | Mother-to-child | |
| Household contacts | 5 | 4 | v.s. Non Mother-to-child | ||
| Blood transfusion | 1 | 0 | 0.036 | 0.016 | |
| Unknown | 3 | 16 | |||
| HBV Genotype | A | 0 | 1 | Genotype C | |
| B | 7 | 10 | v.s. Non genotype C | ||
| C | 44 | 45 | 0.445 | 0.221 | |
| D | 1 | 1 |
*Data of 51 patients were available.
**Of the 57 patients, 17 patients archived seroconversion.
*** Of the 57 patients, 23 patients were positive for serum HBV DNA and the remaining 28 patients were negative for HBV DNA.
****Omitted from model in order to permit convergence to finite maximim likelihood estimates.