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. 2014 Jan 31;3:2. doi: 10.1186/2045-9769-3-2

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© Harreither et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Overview of the investigated peptides. (A) Oct4-PTD derives from the third helix of the homeodomain (orange) of the transcription factor Oct4 (POU5F1), which possesses a POU-specific and a homeodomain [42], pdb: 3L1P. (B) The sequence alignment of Oct4-PTD and Penetratin shows great conservation, almost half of the residues are identical (*), more than two thirds of the peptide share at least same charge (* or :) (C, D) Helical wheel projection of Oct4-PTD or penetratin.