Figure 5. High-resolution openings of the 4RK-G551D-CFTR Cl⁻ channel.

A, representative recording of a single 4RK-G551D-CFTR Cl⁻ channel in an excised inside-out membrane patch. B, six examples of openings of 4RK-G551D-CFTR taken from the indicated positions (a–f) in A. Dotted lines indicate where channels are closed and downward deflections correspond to channel openings. Traces were filtered at 500 Hz and digitised at either 1 kHz (top) or 5 kHz (bottom).