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. 2014 Mar 27;592(Pt 9):1975–1992. doi: 10.1113/jphysiol.2013.266957

Figure 1. Activation of a 20 pS channel by hypoxia.

Figure 1

A, TASK channels are active in a cell-attached patch of rat glomus cells in normoxia (tracing a). Pipette solution contained 140 mm K+ and pipette potential was +20 mV. Perfusion with hypoxic solution inhibited TASK activity (tracing b) followed by activation of channels with a long open time duration (tracings c and d). Return to normoxic solution closed the channels with the long open time duration and restored TASK activity to the pre-hypoxia level. B, channel openings from a cell-attached patch are shown at various pipette potentials as indicated during perfusion with hypoxic solution. Opening of both TASK and the 20 pS channel are shown. In this patch, the zero current was observed when the pipette potential is −30 mV. C, I–V relationship. Each point is the mean ± SD (n = 3).