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. 2014 Nov 15;25(23):3798–3812. doi: 10.1091/mbc.E14-03-0818

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© 2014 Prakasam et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — ADAM17 expression in the uroepithelium. (A–C) Cryosections of rat bladder uroepithelium were reacted with antibodies specific for ADAM17 (A), a mixture of antibody and inhibitory peptide (B), or antibodies specific for ADAM17 and uroplakin 3a (C). After incubation with fluorophore-labeled secondary antibodies, the samples were analyzed using confocal microscopy. Where indicated, actin was labeled with phalloidin and nuclei were labeled with TOPRO-3. The umbrella cells are marked with the asterisk in the merged images and the apicolateral junction is indicated by arrowheads; scale bar, 10 μm. (D) Rabbit uroepithelium was pretreated with Tapi-2 (15 μM) or GM6001 (15 μM) for 90 min, CCPA (500 nM) was added, and C_T was recorded. Control CCPA data are reproduced from Figure 1B. Data are mean ±SEM (n ≥ 3), and values significantly different (p < 0.05) from CCPA alone are marked with an asterisk.