Table 1.
Patient characteristics and laboratory values at baseline, 24W and 72W
|
Characteristic |
SC |
Non-SC |
||||
|---|---|---|---|---|---|---|
| Baseline | 24W | 72W | Baseline | 24W | 72W | |
| Age (years) |
29.8 ± 8.9 |
- |
- |
34.4 ± 9.1 |
- |
- |
| Gender (M/F) |
7/2 |
- |
- |
9/2 |
- |
- |
| ALT (U/L) |
240.2 ± 67.8a |
29.7 ± 11.0 |
19.4 ± 9.0* |
156.7 ± 41.9a |
48.2 ± 23.4 |
48.6 ± 35.9▲ |
| TBiL (μmol/L)# |
19.3 ± 8.8a |
14.4 ± 4.9 |
12.7 ± 4.7 |
13.1 ± 3.7a |
14.4 ± 3.2 |
11.6 ± 4.3 |
| ALB (g/L)# |
44.3 ± 1.8 |
47.3 ± 2.7 |
47.3 ± 0.7 |
45.3 ± 2.1 |
48.3 ± 3.3 |
47.4 ± 3.2 |
| HBV DNA (log10 cps/ml)§ |
8.91 ± 0.56 |
4.07 ± 1.32 |
2.1 ± 0.04 |
8.46 ± 0.73 |
4.06 ± 1.30 |
2.53 ± 0.50 |
| HBsAg (log10 IU/ml) |
4.15 ± 0.53 |
3.15 ± 0.25** |
2.93 ± 0.42 |
3.86 ± 0.91 |
3.43 ± 0.73▲ |
3.16 ± 0.41 |
| HBV genotype | 5B, 4C | - | - | 7B, 4C | - | - |
These values expressed as mean ± SD, unless otherwise indicated.
Normal values: ALT, ≤ 48 U/L; TBiL, ≤ 22 μmol/L; ALB, 32 ~ 50 g/L.
*P <0.05, comparing with week 24; **P <0.001, comparing with baseline; ▲P >0.05, comparing with baseline or week 24.
§P <0.001, among SC or non-SC groups; #P >0.05, among SC or non-SC groups.
aP <0.001, comparison between SC and non-SC groups at baseline.
ALT, alanine transaminase; ALB, albumin; DNA, deoxyribonucleic acid; HBV, hepatitis B virus; TBiL, Total bilirubin; −, useless; non-SC, non HBeAg seroconversion; SC, HBeAg seroconversion.
All subjects were of Chinese Han ethnicity.