Table 1.
Treatment | Dose (mg/kg) |
Parasitaemia level (log number)/ml |
Mean survival time (days) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
D0 | D2 | D4 | D6 | D8 | D10 | D12 | D14 | |||
DCM ext |
100 |
6.68 ± 0.23 |
7.08 ± 0.25 |
7.57 ± 0.26bc |
7.83 ± 0.14bcd |
6.31 ± 0.46cd |
6.70 ± 1.37c |
7.31 ± 0.44cd |
6.41 ± 1.34c |
34.33 ± 4.63 |
DCM ext |
200 |
7.05 ± 0.18 |
7.04 ± 0.23 |
5.65 ± 1.18bc |
3.80 ± 1.20a |
3.92 ± 1.37a |
6.70 ± 0.30c |
6.78 ± 0.39c |
7.07 ± 0.32c |
37.83 ± 3.49 |
DCM ext |
400 |
7.00 ± 0.30 |
6.95 ± 0.26 |
4.90 ± 0.98ac |
2.80 ± 1.26a |
1.95 ± 1.24a |
3.70 ± 1.17a |
4.85 ± 0.99abc |
4.95 ± 1.01a |
40.67 ± 2.42 |
DA |
3.5 |
7.09 ± 0.06 |
1.25 ± 1.25 |
1.90 ± 1.20a |
3.30 ± 1.48a |
4.60 ± 1.48c |
6.12 ± 1.26c |
7.41 ± 0.40cd |
7.92 ± 0.27c |
36.83 ± 4.36 |
DA |
28 |
7.13 ± 0.05 |
0.00 ± 0.00 |
0.00 ± 0.00a |
0.00 ± 0.00a |
0.00 ± 0.00ab |
0.00 ± 0.00f |
0.90 ± 0.90e |
1.85 ± 1.17f |
42.00 ± 0.00 |
Distilled water | 1 ml | 6.94 ± 0.26 | 7.97 ± 0.12 | 8.67 ± 0.10 | 8.54 ± 0.07 | 8.46 ± 0.17 | 8.70 ± 0.06 | 8.14 ± 0.27 | 8.45 ± 0.21 | 34.33 ± 6.15 |
Values are mean ± SEM; n = 6; D = day; D0 = the day treatment commenced; SEM = standard error of mean; DCM = Dichloromethane; ext = extract; DA = Diminazene aceturate; All superscripts indicate significance at p < 0.05 (a = compared to negative control; b = compared to 3.5 mg/kg DA; c = compared to 28 mg/kg DA; d = compared to 400 mg/kg; e = compared to all groups, f = compared to all groups but 400 mg/kg).