Table 2.
Treatment | Dose (mg/kg) |
Parasitaemia level (log number)/ml |
Mean survival time (days) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
D0 | D2 | D4 | D6 | D8 | D10 | D12 | D14 | |||
80% MeOH ext |
100 |
7.16 ± 0.18 |
8.10 ± 0.17 |
7.80 ± 0.28bc |
7.92 ± 0.26bcd |
7.88 ± 0.16c |
8.23 ± 0.21c |
7.82 ± 0.16c |
8.45 ± 0.13c |
35.17 ± 6.49 |
80% MeOH ext |
200 |
7.02 ± 0.09 |
7.90 ± 0.08 |
7.57 ± 0.24bc |
6.90 ± 0.49c |
6.70 ± 0.47c |
7.95 ± 0.24c |
7.69 ± 0.33c |
8.10 ± 0.27c |
36.50 ± 5.09 |
80% MeOH ext |
400 |
7.17 ± 0.32 |
7.83 ± 0.28 |
6.05 ± 0.36bc |
3.00 ± 1.36a |
3.87 ± 1.37a |
4.90 ± 1.00ac |
7.30 ± 0.12c |
7.15 ± 0.31c |
38.17 ± 4.88 |
DA |
3.5 |
7.09 ± 0.06 |
1.25 ± 1.25 |
1.90 ± 1.20ad |
3.30 ± 1.48a |
4.60 ± 1.48c |
6.12 ± 1.26c |
7.41 ± 0.40c |
7.92 ± 0.27c |
36.83 ± 4.36 |
DA |
28 |
7.13 ± 0.05 |
0.00 ± 0.00 |
0.00 ± 0.00ad |
0.00 ± 0.00a |
0.00 ± 0.00ab |
0.00 ± 0.00e |
0.90 ± 0.90e |
1.85 ± 1.17e |
42.00 ± 0.00 |
Distilled water | 1 ml | 6.94 ± 0.26 | 7.97 ± 0.12 | 8.67 ± 0.10 | 8.54 ± 0.07 | 8.46 ± 0.17 | 8.70 ± 0.06 | 8.14 ± 0.27 | 8.45 ± 0.21 | 34.33 ± 6.15 |
Values are mean ± SEM; n = 6; D = day; D0 = the day treatment commenced; SEM = standard error of mean; MeOH = Methanol; ext = extract; DA = Diminazene aceturate; All superscripts indicate significance at p < 0.05 (a = compared to negative control; b = compared to 3.5 mg/kg DA; c = compared to 28 mg/kg DA; d = compared to 400 mg/kg; e = compared to all groups).