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. 2014 Sep 21;4:72. doi: 10.1186/s13568-014-0072-5

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Copyright © 2014 Moriuchi et al.; licensee Springer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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The β-HCH degradation activities of LinB_UT, LinB_MI, and their intermediate mutants. Specificity constants of LinB_UT (vertical hexagon), LinB_MI (circle), and their intermediate mutants (single, open triangle; double, horizontal hexagon; 3-point, pentagon; 4-point, square; 5-point, diamond; and 6-point, closed triangle) for the first conversion (from β-HCH to PCHL: X axis) and the second conversion (from PCHL to TCDL: Y axis) steps (Table 1) were plotted in logarithmical values. The effects of A112V (b), I138L (c), M253I (d), A81T (e), and A135T (f) mutations were extracted from the total plot (a) and shown by arrows. One potential evolutionary route from LinB_UT to LinB_MI by the accumulation of seven point mutations is shown by arrows (a).