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. 2013 Jun 14;1:10. doi: 10.1186/2193-9616-1-10

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© Dancik et al.; licensee Springer. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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trans -Capsaicin (CAP) (a) steady-state plasma concentrations and (b) exposure conversion factors in logarithmic scale. Dose, exposures scenarios and application conditions are described in Tables 1 and 2. (c) Comparison of the steady-state flux cleared from the dermis into the systemic circulation obtained from scenarios A and B. Scenario A yields a finite dose flux while B yields a steady-state flux equivalent to an infinite dose application. The solid horizontal line shows the average steady-state flux calculated (Eq. 5) calculated for scenario A.