Table 2.
MRS Study group: metabolite concentrations in the white matter and hippocampus single voxels across the four study groups and selected individuals
| Metabolite: single-voxel location |
Group | Statistics | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. FAS/PFAS (n=20) |
2. SE/AE (n=24) |
3. ND/AE (n=21) |
4. Control (n=16) |
ANOVA |
|||||||||
| Overall | Post hoc Duncan | A priori linear trend a |
|||||||||||
| Concentration (mM) |
Concentration (mM) |
Concentration (mM) |
Concentration (mM) |
Fb | P | Homologous groups |
Fc | P | |||||
| Mean | (S.D.) | Mean | (S.D.) | Mean | (S.D.) | Mean | (S.D.) | ||||||
| Cho | |||||||||||||
| White matter | 1.24 | (.17) | 1.37 | (.19) | 1.32 | (.19) | 1.39 | (.14) | 2.7 | (.05) | 1,234 | 0.04 | (.84) |
| Hippocampus | 1.31 | (.23) | 1.42 | (.21) | 1.40 | (.25) | 1.42 | (.17) | 1.1 | (.36) | 0.01 | (.92) | |
| NAA | |||||||||||||
| White matter | 8.10 | (1.00) | 8.45 | (1.09) | 8.48 | (1.23) | 8.31 | (1.15) | 0.5 | (.66) | 0.30 | (.56) | |
| Hippocampus | 6.89 | (.94) | 7.22 | (1.07) | 6.95 | (1.33) | 7.33 | (.98) | 0.7 | (.58) | 0.80 | (.38) | |
| Cre | |||||||||||||
| White matter | 5.47 | (.57) | 5.73 | (.67) | 5.75 | (.72) | 5.60 | (.88) | 0.7 | (.55) | 0.30 | (.59) | |
| Hippocampus | 5.34 | (.69) | 5.43 | (.78) | 5.33 | (.69) | 5.32 | (.59) | 0.1 | (.96) | 0.04 | (.84) | |
| Cho/Cre | |||||||||||||
| White matter | .229 | (.033) | .242 | (.046) | .233 | (.041) | .251 | (.032) | 1.1 | (.35) | 0.40 | (.53) | |
| Hippocampus | .246 | (.033) | .263 | (.039) | .262 | (.029) | .270 | (.037) | 1.5 | (.22) | 0.30 | (.61) | |
| NAA/Cre | |||||||||||||
| White matter | 1.48 | (.16) | 1.49 | (.26) | 1.48 | (.13) | 1.49 | (.17) | 0.03 | (.95) | 0.01 | (.93) | |
| Hippocampus | 1.30 | (.19) | 1.35 | (.25) | 1.31 | (.23) | 1.39 | (.21) | 0.5 | (.67) | 0.80 | (.36) | |
Duncan: The Duncan multiple comparison range test is reported if the overall ANOVA is statistically significant; commas separate groups with homogeneous means at P<.05. F: F-statistic. Linear trend: ANOVA unweighted linear trend across the four study groups. N/A: Not applicable.
a
Linear trends involving Cho and Cho/Cre were assessed across three groups (control, ND/AE, SE/AE). All other linear trends were assessed across all four groups.
b
Numerator degrees of freedom (df)=3; denominator df=total sample size minus 4.
c
Numerator df=1; denominator df=total sample size minus number of groups.