Table 3.

MRS-MRI: Pearson correlation coefficients between the size of brain regions and absolute Cho and NAA concentrations in the left hippocampus and right white matter voxels

Brain structure	Choline concentration (mM)		NAA Concentration (mM)
	Left hippocampus voxel hCho	Right white matter voxel wCho	Left hippocampus voxel hNAA	Right white matter voxel bNAA
Total brain volume (cm3)	.270**	.134	.042	.187
Total brain midsagittal area (cm2)	.188	.200	.166	.142
Frontal lobe volume (cm3)	.320**	.208	.028	.159
Frontal lobe gray matter volume (cm3)	.287**	.151	.095	.126
Frontal lobe white matter volume (cm3)	.298**	.263*	− 0.42	.203
Corpus callosum
Midsagittal area (cm2)	.280**	.448**	.141	.162
Length (cm)	.258*	.363**	.036	.104
Region 1: genu midsagittal area (cm2)	.145	.310**	.052	.125
Region 2: midsagittal area (cm2)	.071	.263**	.074	.147
Region 3: midsagittal area (cm2)	.245*	.379**	.028	.208*
Region 4: midsagittal area (cm2)	.257*	.257*	.063	.071
Region 5: splenium midsagittal area (cm2)	.189	373**	.006	.071
Cerebellar vermis
Midsagittal area (cm2)	.197	.197	−.043	.097
Lobules 1–5: midsagittal area (cm2)	.114	.277**	−.121	.112
Lobules 6–7: midsagittal area (cm2)	.307**	.075	.075	.033
Lobules 8–10: midsagittal area (cm2)	−.028	.144	−.104	.102
Right caudate volume (cm3)	.079	−.019	−.078	.130
Left caudate volume (cm3)	.005	−.027	−.067	−.008
Total caudate volume (cm3)	.041	−.023	−.073	.059
Right putamen volume (cm3)	.285**	.193	.011	.136
Left putamen volume (cm3)	.169	.135	.047	−.054
Total putamen volume (cm3)	.243*	.175	.030	.046
Right hippocampus volume (cm3)	.077	.195	.049	.137
Left hippocampus volume (cm3)	.220*	.155	.124	.082
Total hippocampus volume (cm3)	.154	.180	.090	.112

^*P<.05.

^**P<.01.