Table 3.
Genes with significantly higher expression (>2 times) in the ivabradine group than in the control group
| Gene name | Function | IVBD (mean) | Control (mean) | FC | P |
|---|---|---|---|---|---|
| MMP -2(matrix metallopeptidase- 2) | ECM | 0.027 | 0.067 | 0.40 | 0.031 |
| MIP-3 β(macrophage inflammation protein-3 β, CCL 19) | Lymphoid T cells | 0.319 | 0.144 | 2.22 | 0.014 |
| 6Ckine(chemokine with 6 cysteines,CCL21) | Lymphoid organs | 0.421 | 0.177 | 2.37 | 0.024 |
| ACE/CD143(angiogensin I Converting Enzyme/CD 143) | RAAS | 0.433 | 0.189 | 2.29 | 0.006 |
| ALK-1(activin receptor-like kinase) | TGF- β | 0.327 | 0.123 | 2.66 | 0.047 |
| CT-1(cardiotrophin-1) | apoptosis | 0.292 | 0.086 | 3.39 | 0.016 |
| CD27(CD-27) | apoptosis | 0.245 | 0.089 | 2.75 | 0.021 |
| CD27 Ligand(CD70) | TNF | 0.212 | 0.067 | 3.16 | 0.020 |
| Endoglin(endoglin) | TGF- β | 0.333 | 0.159 | 2.09 | 0.005 |
| Epigen(epigen) | EGF-like | 0.173 | 0.0845 | 2.05 | 0.039 |
| IL-17E(interlukin-17E) | T cells | 0.327 | 0.161 | 2.03 | 0.001 |
| IL-17 F(interlukin-17 F) | T cells | 0.385 | 0.163 | 2.36 | 0.001 |
| IL-1ra/IL-1 F3(interlukin-1ra/-1 F3) | T cells | 0.266 | 0.121 | 2.19 | 0.003 |
| IL-2 Rα(interlukin-2 Rα) | T cells | 0.298 | 0.143 | 2.08 | 0.001 |
Fold changes are relative to normal samples.
FC, fold change; ECM, extracellular matrix; RAAS, renin angiotensin aldosterone system; TGF, tissue growth factor; TNF, tumor necrosis factor; EGF, epidermal growth factor.