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. 2014 Nov 13;10(11):e1004764. doi: 10.1371/journal.pgen.1004764

Figure 6. ERK7 acts downstream of p53.

Figure 6

(A) Overexpression of p53 in the IPCs (dILP2-Gal4) leads to increased erk7 mRNA levels as detected by in situ hybridization. (B, C) Knockdown of ERK7 suppresses dILP2 accumulation following p53 overexpression. Error bars represent standard deviation, (N≥10 brains). (D) Knockdown of ERK7 in the IPCs rescues the small pupal size caused by p53 overexpression. Error bars represent standard deviation (N = 3, 10 pupae/group). (E) ERK7 depletion in the IPCs partially rescues the developmental delay caused by p53 overexpression. Error bars represent standard deviation (N = 4, 30 larvae/group). **p<0.01, ***p<0.001 (Student's t-test).