Table 2. Pleiotropy estimated among five psychiatric disorders.
LRT | p-value | |||||
ADHD-ASD | 0.900 (0.009) | 0.007 (0.006) | 0.093 (0.009) | 0.001 (0.004) | 0.913 | 0.339 |
ADHD-BPD | 0.822 (0.008) | 0.001 (0.005) | 0.164 (0.009) | 0.013 (0.007) | 29.849 | 4.670e-08 |
ADHD-MDD | 0.776 (0.036) | 0.006 (0.010) | 0.217 (0.036) | 0.001 (0.010) | −0.005 | 1 |
ADHD-SCZ | 0.804 (0.005) | 0.001 (0.004) | 0.183 (0.008) | 0.012 (0.007) | 15.855 | 6.837e-05 |
ASD-BPD | 0.791 (0.008) | 0.027 (0.007) | 0.115 (0.009) | 0.067 (0.008) | 69.391 | 8.074e-17 |
ASD-MDD | 0.727 (0.033) | 0.049 (0.016) | 0.180 (0.033) | 0.044 (0.016) | 2.717 | 0.099 |
ASD-SCZ | 0.771 (0.006) | 0.035 (0.006) | 0.131 (0.007) | 0.064 (0.006) | 106.493 | 5.749e-25 |
BPD-MDD | 0.793 (0.014) | 0.011 (0.026) | 0.030 (0.015) | 0.166 (0.027) | 126.037 | 3.017e-29 |
BPD-SCZ | 0.821 (0.004) | 0.001 (0.005) | 0.013 (0.006) | 0.165 (0.007) | 1851.727 | 0 |
MDD-SCZ | 0.809 (0.009) | 0.001 (0.010) | 0.001 (0.025) | 0.189 (0.025) | 466.312 | 2.034e-103 |
The values in the brackets are standard errors of the estimates. The last two columns provide the LRT statistics and p-values of hypothesis testing (15).