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. 2014 Aug 13;28(10):891–902. doi: 10.1177/0269881114543719

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© The Author(s) 2014

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 5. — Vortioxetine enhanced theta burst long-term potentiation (LTP) in hippocampal slices.

Representative traces of field excitatory post-synaptic potential (fEPSP) recordings from vehicle-treated, vortioxetine-treated and escitalopram-treated slices are shown on top of the graph. Each trace is the mean of five sweeps taken either immediately before (dashed line marked with (1) or 50 min after (solid line marked with (2)) theta-burst stimulation (TBS). TBS, marked with an arrow in the time course graph, induced a long-lasting increase in the slopes of fEPSPs. For each time point, fEPSP slopes were calculated from either vehicle-treated (n=17 slices from 12 animals), vortioxetine-treated (n=14 from nine animals) or escitalopram-treated slices (n=5 slices from four animals) and expressed as % of baseline. Data are shown as the mean±standard error of the mean (SEM). Perfusion of hippocampal slices with vortioxetine for 30 min prior to TBS increased LTP without affecting baseline transmission (p=0.0017 vortioxetine vs vehicle, two-way analysis of variance (ANOVA) F_(2,38)=7.548)). Escitalopram had no effect on LTP (p>0.05).