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. 2014 Aug 13;28(10):891–902. doi: 10.1177/0269881114543719

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© The Author(s) 2014

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 6. — Vortioxetine increased frontal cortical theta power in in vivo electroencephalography (EEG) recordings. (a1) Total relative theta power are shown for each treatment for every 15 min from 0–180 min postdose. A treatment effect was observed for vortioxetine (VOR), but not escitalopram (p=0.0226, one-way analysis of variance (ANOVA) F_(65,497)=1.4180). (a2) Pharmacologically-induced changes in EEG recordings were quantified by averaging the 10 s bins constituting 15–75 min before (baseline) and 45–90 min post-drug treatment. Theta power was expressed as the percentage change from baseline. Bar graphs represent the mean±standard error of the mean (SEM) (n=9 rats per condition). A negative value indicates a decrease in EEG power from baseline. Vortioxetine at 5.0 and 10 mg/kg significantly increased theta power (*p<0.05, post-dose versus vehicle, one-way analysis of variance (ANOVA) with least significant difference (LSD) post-hoc comparison). Escitalopram at 2.0 mg/kg had no effect on theta power.