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. 2014 Nov 13;10(11):e1004784. doi: 10.1371/journal.pgen.1004784

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Structural mappings of the large and small ribosomal subunits, showing protein monomers with predicted low (red) and high (blue) pI. Subunits are oriented according to (A) complex formation, (B) cytoplasmic view of each subunit, and (C) internal view of each subunit. Subunits exposed to the cytoplasm tend to be acidified (red subunits, visible in B), while subunits buried within the ribosome tend to have an alkaline isoelectric point (blue subunits, visible in C). Structural models used were those for Thermus thermophilus (1FKA) [97] and Haloarcula marismortui (1QVG) [96].