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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Rapid Commun Mass Spectrom. 2014 Dec 15;28(23):2511–2522. doi: 10.1002/rcm.7051

Table 1.

Alkylation reagents of increasing hydrophobicity

Alkylation Agent NPSA(Å2)
Tag 1 graphic file with name nihms637495t1.jpg 2-lodoacetamide (IAM) 20
Tag 2 graphic file with name nihms637495t2.jpg N-Ethylmaleimide (NEM) 77
Tag 3 graphic file with name nihms637495t3.jpg N-(Tert-Butyl)-2-lodoacetamide (NTB) 107
Tag 4 graphic file with name nihms637495t4.jpg N-(2,4-Dimethylphenyl)-2-lodoacetamide (NDMP) 145
Tag 5 graphic file with name nihms637495t5.jpg N-(2,6-Diethylphenyl)-2-lodoacetamide (NDEP) 230