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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Rapid Commun Mass Spectrom. 2014 Dec 15;28(23):2511–2522. doi: 10.1002/rcm.7051

Table 2.

Calculated nonpolar surface area of peptides used for site occupancy measurements

graphic file with name nihms637495t6.jpg
KirCII DSZS DSZS DSZS
Unmodified NPSA(Å2): VEPDAVTGHSMGE
626		 APPDFLAGHSLGE
690		 EAPPDFLAGHSLGE
736		 EEAPPDFLAGHSLGE
782
Extender Unit (R) NPSA (Å2) NPSA (Å2) of Modified Peptides
1 hydroxy 8 634 698 744 790
2 malonyl (H) 19 645 709 755 801
3 methoxy 38 664 728 774 820
4 methyl 38 664 728 774 820
5 azidoethyl 46 672 736 782 828
6 propargyl 49 675 739 785 831
7 cyclopropyl 53 679 743 789 835
8 ethyl 57 683 747 793 839
9 allyl 71 697 761 807 853
10 isopropyl 76 702 766 812 858
11 propyl 76 702 766 812 858
12 phenyl 84 710 774 820 866
13 butyl 95 721 785 831 877
14 isobutyl 95 721 785 831 877
15 t-butyl 95 721 785 831 877
16 pentyl 114 740 804 850 896
17 phenylethyl 122 748 812 858 904