Table 2. Ratio between stimulatory and inhibitory motifs in trypanosomatidae and vertebrate genomes.
S/I | L. major | T. cruzi | T. brucei | T. vivax | Mouse | Human |
A/C | 15.5 | 12.4 | 10.5 | 13.3 | 1.6 | 1.4 |
A/D | 10.2 | 9.9 | 8.6 | 13.2 | 1.6 | 2.1 |
B/C | 1.5 | 2.1 | 2.4 | 2.5 | 0.3 | 0.3 |
B/D | 1.0 | 1.7 | 2.0 | 2.5 | 0.3 | 0.4 |
A- RRCGYY | 197597 | 105362 | 82685 | 70098 | 1490164 | 1665432 |
B- HRWCGTTN | 18555 | 17819 | 18976 | 13428 | 309431 | 347034 |
C- CCNDDNNGGG | 12726 | 8478 | 7873 | 5267 | 936758 | 1183790 |
D- WKKVGGGG | 19451 | 10625 | 9605 | 5305 | 944031 | 787326 |
The table shows the S/I ratio that corresponds to (number of stimulatory motif/number of inhibitory motif) calculated for each motif and genome. The number of motifs observed in each genome is reported as in Table 1, A and B corresponding to the stimulatory motifs and C and D to the inhibitory ones. The S/I ratios are significantly higher in trypanosomatidae DNA than in mouse DNA, according to Wilcoxon test (p<0.5).