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. 2014 Nov 13;9(11):e111838. doi: 10.1371/journal.pone.0111838

Figure 3. Effects of BAY 85-3934 or recombinant human erythropoietin (rhEPO) on erythropoietic parameters in cynomolgus monkeys.

Figure 3

Data are presented as means ± SEM. (A) Plasma erythropoietin (EPO) concentrations after repeat oral administration of BAY 85-3934 (n = 6 animals per group). (B) Plasma EPO concentrations after a single s.c. administration of rhEPO (100 IU/kg) or a single oral dose of BAY 85-3934 (1.5 mg/kg) (n = 3 animals per group). (C) Erythropoietic parameters (hemoglobin [HGB], red blood cells [RBCs], and reticulocytes) after s.c. administration of rhEPO twice weekly (100 IU/kg) for 2 weeks or BAY 85-3934 (1.5 mg/kg) once daily for 2 weeks (n = 3 animals per group).