Table 1. Descriptive data from the region of interest (ROI) analysis using standard templates.

	ROI size	Reference group			Multiple Sclerosis group
Structure	(voxels)	R (s)	R (s)	PD (%)	R (s)	R (s)	PD (%)
Lateral ventricles	2349	0.720.56	6.64.2	8514	0.400.47	4.13.7	9212
Insula	3628	0.940.35	9.82.7	809	0.870.39	9.03.1	8110
Cingulate cortex	7655	1.090.36	10.72.2	779	0.960.39	9.72.8	8010
Caudate nucleus	1956	1.080.43	10.53.4	7810	0.750.51	7.44.5	8511
Cortical gray matter	53401	1.020.57	10.03.2	7520	0.920.61	9.13.5	7720
Pons	2518	1.060.43	9.83.5	7611	0.940.50	8.64.2	7814
Putamen	2073	1.290.18	12.91.2	745	1.250.21	12.41.5	746
Mid brain	2289	1.180.36	10.83.0	748	1.100.39	10.13.4	769
Thalamus	2157	1.290.25	12.11.9	737	1.120.41	10.63.5	7610
Occipital white matter	11077	1.220.36	11.61.9	749	1.130.34	11.12.2	769
Frontal white matter	40008	1.170.46	10.82.7	7414	1.050.48	9.93.1	7714
Parietal white matter	14362	1.180.40	11.02.5	7411	1.060.42	10.23.0	7712
Sublobar white matter	12855	1.250.41	10.92.8	7310	1.090.48	9.63.6	7612
White matter	106935	1.200.41	11.12.4	7412	1.070.43	10.22.9	7712
Corpus callosum	2685	1.200.55	9.73.7	7313	0.990.59	8.14.1	7714

The table shows ROI sizes, mean R, R, and proton density (PD) values, and standard deviations of 15 pre-defined structures in the Montreal Neurological Institute (MNI) standard brain template. All comparisons between the reference group and the multiple sclerosis group were highly significant, p0.001.