Figure 3.

(a) TACs derived from the rat brain PET images [¹⁸F]3 (n = 7). (b) mGlu4 blocking studies demonstrated reduced uptake in the brain regions by 10–20%, while mGlu5 blocking agents displayed minimal blocking effect indicating good selectivity to mGlu4. Tissue uptake was calculated as area under TAC expressed as (% dose/cc) × min: Str = striatum, Hipp = hippocampus, Thal = thalamus, Cort = cortex, Cereb = cerebellum, WB = whole brain. Shown are results from baseline studies (n = 7), mGlu4 (2) blocking studies (n = 4), and mGlu5 (MTEP) blocking studies (n = 3). (c) Percentage of [¹⁸F]3 in the plasma over time. (n = 2).