Figure 1. Co-transmission in the sympathetic nervous system.
Stimulation of a sympathetic ganglion neuron revealed (a) a fast, nicotinic EPSP (left) and higher stimulation evoked an action potential (right). (b and c)Such stimuli can also elicit a slow muscarinic IPSP (b) or EPSP (c) depending on the stimulation conditions. (d) Strong stimulation generated a late slow EPSP consistent with co-transmission by the neuromodulator LHRH. Note timescale difference in each panel. Adapted from Figure 1 of Jan et al., 1979.