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. 2014 Nov 13;9(11):e112571. doi: 10.1371/journal.pone.0112571

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© 2014 Azevedo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Parasites expressing the secreted (SP) or the exported (PEXEL) Nluc were treated with Brefeldin A (BFA) for 6 hours and luciferase activity determined in each sub-cellular fraction. Results are the mean of 4 experiments and the error bars represent standard deviations. Statistical significance (* p<0.05) was determined by 2 way ANOVA test comparing the activity detected in the parasite fraction of treated and DMSO control parasites of each line and of PV and RBC fractions of DMSO against treated SP-Nluc and PEXEL-Nluc lines respectively. (B) The toxicity of each treatment was determined by measuring total luciferase activity as relative to the DMSO control.