Figure 1. Effects of cranial irradiation on blood-brain barrier permeability in mice.

Single head irradiation with 0.1, 2 and 10 Gy doses was performed on 10-week-old adult (A) and 10-day-old infant mice (B). BBB permeability for albumin was measured 1 day, 1, 4 and 26 weeks postirradiation and expressed as ng of Evans blue/mg of tissue. Values presented are means ± SD, n = 5–12 from 2–3 separate experiments. Statistical analysis: two-way ANOVA followed by Bonferroni post-test. Statistically significant differences p<0.05 (*); p<0.01 (**) and p<0.001 (***) are indicated compared to sham treated animals examined at the same time point. EB: Evans blue.