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. 2014 Nov 13;9(11):e112669. doi: 10.1371/journal.pone.0112669

Figure 6. L27/01F increases recruitment of host cells to the lungs, but decreases cytokine production.

Figure 6

L27/01 and L27/01F strains elicit different inflammatory response in C57/BL6 mice. Mice (n = 8) were inoculated i.t. with 106 yeast cells of L27/01 or L27/01F strains. After 1, 7, 15 or 30 days post infection, the mice were euthanized and mononuclear leukocytes (A) and neutrophils (B) in bronchoalveolar lavage fluid (BALF) were quantified. Neutrophilic infiltrate in the lungs was also determined as MPO activity and expressed as relative number of neutrophils (C). Levels of CXCL1/KC (D), IFN-γ (E), TNF-α (F) and IL-10 (G) are expressed in pg per 100 mg of lung. White bars refer to not infected (NI) animals, black bars to animals infected with the L27/01 strain, and grey bars to animals infected with the L27/01F strain. The results are presented as the mean ± SEM. Each experiment was performed in triplicate. *P<0.05 was considered to be significant.