Table 2. Association between the stage of AMD and serum complement catabolism.

Clinical Age-Related Maculopathy Staging (CARMS)for both eyes	Mean C3d/C3ratio (SE)	No. (%)	p*
Grade 2 in both eyes (2:2)	1.64 (0.30)	4 (5.6)	1.000
Grade 2 in the first eye and grade 4 or 5 in thesecond eye (2:4–5)	1.69 (0.31)	9 (12.7)	1.000
Grade 3 in both eyes (3:3)	1.86 (0.17)	10 (14.1)	0.263
Grade 3 in the first and stages 4 or 5 in the secondeye (3:4–5)	2.01 (0.20)	19 (26.8)	0.006
Grades 4 or 5 in both eyes (4–5:4–5)	1.32 (0.06)	29 (40.8)	Ref.

Compared to the patients with intermediate AMD in one eye and late AMD in the other eye (CARMS stage 3∶4–5), the patients who had late AMD in both eyes (CARMS 4–5∶4–5) had significantly lower C3d/C3 levels (p = 0.006).

*p-value from one-way ANOVA with post hoc Bonferroni correction.