Skip to main content
. 2014 Nov 13;9(11):e112787. doi: 10.1371/journal.pone.0112787

Figure 1. Characteristics of knock-out and heterozygous knock-out mouse models.

Figure 1

Figure shows mouse characteristics in the cholesterol synthesis (A), bile acid synthesis pathways (B) and lipid transporters (C). In red are marked disease phenotypes, while in green are marked mild/no phenotype. *The heterozygous knock-out models often were not thoroughly investigated. Gene names and references to literature describing mouse models: Acat2 acetyl-coenzyme A acetyltransferase 2; Hmgcs1 3-hydroxy-3-methylglutaryl-coa synthase 1; Hmgcr 3-hydroxy-3-methylglutaryl-coa reductase [55]; Pmvk phosphomevalonate kinase; Mvd diphosphomevalonate decarboxylase; Mvk mevalonate kinase [56]; Idi1 isopentenyl-diphosphate delta isomerase 1; Ggps1 geranylgeranyl diphosphate synthase 1; Fdps farnesyl diphosphate dynthase; Fdft1 farnesyl-diphosphate farnesyltransferase 1 [57]; Sqle squalene epoxidase; Lss lanosterol synthase; Cyp51 lanosterol 14-alpha-demethylase [17], Tm7sf2 C-14 sterol reductase; Lbr lamin-B receptor; Sc4mol methylsterol monooxygenase 1*(WTSI); Nsdhl NAD(P) dependent steroid dehydrogenase-like [58], [59]; Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 [60]; Sc5d lathosterol oxidase [61]; Dhcr7 7-dehydrocholesterol reductase [62]; Ebp emopamil binding protein (sterol isomerase) [63]; Dhcr24 24-dehydrocholesterol reductase [41], [64]; Cyp7a1 cholesterol 7-alpha-monooxygenase [65], [66]; Hsd3b7 3 beta-hydroxysteroid dehydrogenase type 7 [67]; Cyp8b1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [68]; Cyp27a1 Sterol 26-hydroxylase [69]; Cyp7b1 25-hydroxycholesterol 7-alpha-hydroxylase [70]; Scrab1 scavenger receptor class b, member 1 [71]; Ldlr low density lipoprotein receptor [72]; Cd36 fatty acid translocase [73], [74]; Abcg5 ATP-binding cassette sub-family g member 5; Abcg8 ATP-binding cassette sub-family g member 8 [75].