Skip to main content
. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: Nat Rev Immunol. 2009 Feb;9(2):106–115. doi: 10.1038/nri2489

Figure 1. The structure of Cd4 and Cd8 loci, illustrating important cis-acting elements.

Figure 1

a | The expression of CD4 is driven by the Cd4 proximal enhancer in all T-cell populations and is restricted to the double-positive and CD4 single-positive thymocyte populations owing to the activity of the Cd4 silencer, which is found in intron 1. The binding of RUNX (runt-related transcription factor) proteins to the Cd4 silencer is necessary for silencer activity. b | The expression of Cd8ab is driven by a series of stage-specific enhancers (known as E8I – E8IV), which have overlapping activity.

HHS Vulnerability Disclosure