Table 1.

Selected antigens expressed on murine macrophages

Ab	Ag	Structure	Ligands	Cellular Expression	Function	Comment
F4/80	F4/80 (EMR1)	EGF-TM7	?	Mature Mϕ, absent T areas; eosinophils	Peripheral tolerance	Useful marker development, microglia
FA-11	Macrosialin (CD68)	Mucin-LAMP	OX-LDL	Pan-Mϕ, DC	Late endosomal	Glycoforms regulated by inflammation and phagocytosis
5C6	CR3 (CD11b, CD18)	β2-integrin	iC3b, ICAM, et al.	Monocytes, Microglia, PMN, NK cells	Phagocytosis, adhesion	Important in inflammatory recruitment, PMN apoptosis
2F8	SR-A (I, II)	Collagenous, type II glycoprotein Isoforms differ, cysteine-rich domain	Polyanions, LTA; LPS; bacterial proteins, e.g. Neisseria; Modified host proteins; β-amyloid, apolipoprotein A, E	Mϕ, Sinusoidal Endothelium	Adhesion Endocytosis Phagocytosis of apoptotic cells and bacteria	Protects host against LPS-induced shock Promotes atherosclerosis Clearance of calciprotein particles
SER-4 3D6	Sn (Siglec-1)	Ig superfamily	Sialyl glycoconjugates e.g. CD43	Subsets Tissue Mϕ	Lectin	Strongly expressed in marginal zone metallophils in spleen and subcapsular sinus of lymph nodes
5D1	Macrophage mannose receptor (CD206)	C-type lectin domains (CRD) and N-terminal cysteine-rich domain (CyRD)	Mannosyl, fucosyl terminal glycoconjugates (CRD) and sulphated sugars (CyRD)	Subsets tissue macrophages	Endocytosis Adhesion	CyRD targets subsets of marginal zone metallophils in spleen.
2A11	Dectin-1	C-type lectin-like receptor hemi-ITAM	β-glucan	Myeloid cells (Mϕ, DC, PMN) ?subsets Lymphocytes	Fungal uptake	Signals via Syk and Card9

Ab, antibody; Ag, antigen; CNS, central nervous system; DC, dendritic cells; ICAM, intercellular adhesion molecule; Ig, immunoglobulin; LAMP, lysosome-associated membrane protein; LPS, lipopolysaccharide; LTA, lipoteichoic acid; Mϕ, macrophages; NK, natural killer cells; PMN, Sn, sialoadhesin; SR-A, type A scavenger receptor. For further information and references consult the text and Taylor et al. ¹¹.