Figure 2. Significantly mutated breast cancer genes with validated splicing mutations.

TP53, KMT2C and CDH1 gene lengths are displayed with both exons (thick lines/boxes) and introns (thin horizontal lines), along with the location of all splicing mutations. Diamond markers denote cryptic mutations, natural splice site mutations are indicated by a circle and the colour of the marker corresponds with breast cancer tumour subtype. Mutations validated by Veridical are found above the gene, and those mutations not assessed or not validated are below.