Table 2. Genes Most Commonly Mutated with Splicing Mutations.

Gene Symbol*	# Splicing Mutations	# Validated	% Validated
TP53	24	18	75
HMCN1	19	9	47
KMT2C (MLL3)	19	7	37
FHAD1	12	4	33
RAB3GAP1	11	4	36
BCLAF1	11	3	27
ANKEF1	10	6	60
RRM1	8	4	50
RPRD1A	7	2	29
SCAMP5	7	2	29
CDH1	6	4	67
ACTR3	6	2	33

*FDR < 0.05 for all genes from MuSiC (Fisher's combined P-value, convolution and likelihood ratio tests).