Figure 7. EBV Strains Carrying Large Deletions.

Map of a generic EBV genome linearized with the restriction endonuclease PacI. The number of terminal and internal repeats 1 can vary in different EBV strains; therefore, broken lines were inserted in the map at these positions. The deletions present in four EBV strains are shown as black bars below the map. Deletion I is 12 kb in size and is present in episomes of cell lines obtained by transformation with B95–8 EBV isolates (Raab-Traub et al. 1980; Parker et al. 1990). This deletion encompasses a portion of the EBV genome corresponding to the central portion of the Raji RRF. The remaining deletions were artificially engineered in the EBV genome. Deletion II is described in Robertson et al. (1994). Deletion III is described in Robertson and Kieff (1995). Deletion IV is described in both Kempkes et al. (1995a) and Kempkes et al. (1995b).