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Short-term (4 weeks) entanercept pharmacodynamics and efficacy in pck rats. (A) Stress kinase phosphorylation from kidney tissue lysates (N = 4) is significantly reduced following 4 weeks dosing with etanercept at various levels. (B) Kidney weight, cyst number, serum urea nitrogen and creatinine are unchanged following etanercept treatment for 4 weeks (N = 10).
