Figure 1.

Inoculation of Candida albicans and treatment protocol of iCo-010 in mice. (A) Inoculation of Candida albicans and treatment protocol of iCo-010 in mice, (B) Comparison of the efficacy of oral AmB at 5, 10 and 20 mg/kg in the lipid-based iCo-010 formulation in the liver, lung, heart, brain spleen and kidney tissues of a mouse model of invasive candidiasis. Animals were infected and allowed to establish the infection over two days. The animals were treated for the next five consecutive days once daily and sacrificed 7 days following the completion of the treatment. Organs were harvested and homogenized to count CFU of the fungus/1ml of tissue homogenate (Mean CFU count ±SEM). *p<0.05 significantly different from the untreated control group. The purple column represents the control group, green column represents 5 mg/kg group, red column represent 10 mg/kg group and blue column represents 20 mg/kg group.