Table 1.
Concentration of AmB (ng/g, Mean +/- SEM) in mouse tissues infected with Candida albicans 7 days after the completion of 5 days oral iCo-010 treatment once daily at 5, 10 and 20 mg/kg doses, (ND; non detectable)
| Organ | AmB concentration (ng/g tissue) | ||
|---|---|---|---|
| |
5 mg/kg (n=15) |
10 mg/kg (n=13) |
20 mg/kg (n=5) |
|
Kidney |
|
|
|
| |
123.1 ± 16.4 |
323.3 ± 51.5 |
494 ± 79.1* |
|
Liver |
|
|
|
| |
ND |
ND |
ND |
|
Spleen |
|
|
|
| |
114.5 ± 26.7 |
202.5 ± 15.6 |
266.5 ± 29* |
|
Lung |
|
|
|
| |
ND |
46.2 ± 1.4 |
78.2 ± 7.5 |
|
Heart |
|
|
|
| |
ND |
45 ± 11.6 |
121.4 ± 50.7 |
|
Brain |
|
|
|
| ND | ND | ND | |
*p<0.05 significantly different from the 5 mg/kg treatment group.