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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: EcoSal Plus. 2009 Aug;3(2):10.1128/ecosalplus.4.4.2. doi: 10.1128/ecosalplus.4.4.2

Fig. 9. Coordination of two polymerases on one β clamp during bypass of a template lesion.

Fig. 9

(A) The two protein binding sites on the two protomers of the β clamp homodimer allow interaction with two DNA polymerases simultaneously. Pol III (blue) retains control of the primer/template during replication under undisturbed conditions. Template lesions (cross) ahead of the polymerase induce Pol III to stall. (B) A translesion polymerase (TLS, green) switches places with the stalled Pol III and takes over the primer/template. (C) The TLS polymerase extends the primed site across the lesion. (D) Once the lesion is bypassed, Pol III regains control of the primer/template and continues high fidelity DNA synthesis.