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. 2013 Oct 28;6:431. doi: 10.1186/1756-0500-6-431

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Copyright © 2013 Rossi et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Network showing interactions between proteins encoded by genes differentially expressed after stimulation of Caco-2 BBE cell monolayers with IL-8. This network includes only differentially expressed genes that encode for proteins interacting with other proteins. Up-regulated genes are shown in shades of red and down-regulated genes in shades of blue; the intensity reflecting the fold-change. Note that the genes encoding the most connected proteins in the central part of the network (CREBBP, EP300, PPARD and HDAC1) were all up-regulated; these genes encode transcriptional regulators involved in lipid metabolism and cell differentiation. The network illustrates the core transcriptome changes modulating downstream processes including cell migration, signalling and differentiation.