Table 3.

Interaction between genetic and environmental determinants on risks for cholangiocarcinoma

Genetic determinants		Environmental determinants		OR	95%CI		P value	Ref.	Ethnic group
					LL	UL
				Adjusted OR
GSTMI	Wild	Anti-OV antibody	Negative	1.00	Reference			Honjo et al[5] 2005	Thai
	Wild		Positive	10.34	1.31	81.63	0.03
	Null		Negative	0.48	0.21	1.11	0.09
	Null		Positive	18.00	3.33	97.40	< 0.01
GSTMI	Wild	Toilet	Inside the house	1.00	Reference
	Wild		Outside or none	0.20	0.04	1.02	0.05
	Null		Inside the house	0.22	0.06	0.88	0.03
	Null		Outside or none	0.25	0.07	0.91	0.04
GSTTI	Wild	Alcohol drinking	Never	1.00	Reference
	Wild		Occasional	3.58	0.71	17.95	0.12
	Wild		Ex-regular	1.28	0.12	14.08	0.84
	Wild		Regular	4.69	0.93	23.51	0.06
	Null		Never	0.75	0.23	2.43	0.63
	Null		Occasional	1.12	0.22	5.80	0.89
	Null		Ex-regular	27.93	1.84	424.60	0.02
	Null		Regular	3.28	0.35	30.91	0.30
				Crude OR
MTHFR 677	CC	Beef sausage	< 1/mo	1.0	Reference			Songserm et al[6] 2012	Thai
	CT		< 1/mo	1.1	0.51	2.37	0.82
	TT		< 1/mo	0.6	0.25	1.53	0.32
	CC		Weekly	0.9	0.45	1.83	0.80
	CT		Weekly	1.2	0.57	2.43	0.65
	TT		Weekly	1.6	0.80	3.31	0.18
	CC		Daily	3.3	1.51	7.07	0.003
	CT		Daily	3.2	1.33	7.62	0.01
	TT		Daily	8.3	2.23	30.82	0.002
MTHFR 1298	AA	Beef sausage	< 1/mo	1.0	Reference
	AC		< 1/mo	1.3	0.63	2.55	0.51
	CC		< 1/mo	0.8	0.28	2.15	0.63
	AA		Weekly	1.3	0.71	2.45	0.39
	AC		Weekly	1.0	0.49	1.79	0.84
	CC		Weekly	3.8	1.48	9.89	0.01
	AA		Daily	3.8	1.71	8.62	0.001
	AC		Daily	3.5	1.56	7.85	0.002
	CC		Daily	18.3	3.68	90.80	< 0.001